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{01} {02} {03} {04} {05} {06} {07} Prophylactic administration of colchicine may be especially important during the first several months of treatment with an antihyperuricemic agent (allopurinol, probenecid, or sulfinpyrazone) because the frequency of acute attacks may be increased when such therapy is initiated. However, colchicine clearance is substantially reduced in patients with alcoholic cirrhosis {35}. Colchicine has been used together with melphalan and prednisone for the treatment of primary amyloidosis {17} {18}. Therapeutic doses of colchicine should be reserved for patients in whom these other agents are contraindicated or ineffective {05}. Colchicine has permitted withdrawal of corticosteroid therapy in some patients with this condition {36} {37} {38}. In patients with gout, colchicine apparently interrupts the cycle of monosodium urate crystal deposition in joint tissues and the resultant inflammatory response that initiates and sustains an acute attack {01} {02}.
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